Propylene-glycol (PG), pharmaceutical purity

What is Propylene Glycol?

Propylene glycol is a synthetic organic compound belonging to the alcohol family. It is a clear, odorless and slightly sweet-tasting liquid that is commonly used in various industries for its unique properties.

Properties and applications

1. Tobacco industry: Propylene glycol is a key ingredient in e-liquids used in electronic cigarettes and vaping devices. It serves as a carrier and produces visible vapor when heated. While the levels used in e-liquids are generally considered safe, it is essential to follow the manufacturer's instructions and use these products responsibly. However, it is important to note that the long-term effects of inhaling propylene glycol in this context are still being studied.

2. Food and Beverages: Propylene glycol is approved for use as a food additive by regulatory authorities in many countries. It is commonly used as a humectant and solvent in food products such as baked goods, dairy products, beverages, and sauces. It helps retain moisture, maintain texture, and improve the overall quality of food and beverage formulations. Regulatory authorities, such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA), have determined that propylene glycol is generally recognized as safe (GRAS) for use in foods and beverages. The FDA specifies that propylene glycol can be used as a food additive in amounts up to 50 grams per kilogram (or 5% by weight) of the final product.

3. Personal care and cosmetics: Propylene glycol is a common ingredient in cosmetics and personal care products. It is used as a moisturizer and solvent in skin care products, hair care products, deodorants and perfumes. It helps improve moisture retention, stability and texture in these formulations. The Cosmetic Ingredient Review (CIR) Expert Panel, which evaluates the safety of cosmetic ingredients, concluded that propylene glycol is safe for use in cosmetic formulations at concentrations up to 50%.

4. Pharmaceutical and medical applications: Propylene glycol is used in the pharmaceutical industry for a variety of purposes. It is commonly used as a solvent in oral and injectable medications, as well as an ingredient in topical creams, ointments, and lotions. Its ability to dissolve and stabilize active ingredients makes it a valuable ingredient in pharmaceutical formulations. The specific concentration of propylene glycol in pharmaceutical and medical products may vary depending on the composition and intended use.

5. Industrial applications: Propylene glycol is widely used as a versatile industrial chemical. It serves as a solvent, humectant, and stabilizer in a wide range of products, including paints, coatings, antifreeze, hydraulic fluids, and industrial cleaners.

Safety & Side Effects. Propylene glycol is generally recognized as safe for its approved uses. However, in rare cases, individuals may experience mild allergic reactions or skin irritation when exposed directly to concentrated forms. As with any chemical, it is recommended to follow recommended usage instructions and consult relevant safety information.
It is important to distinguish propylene glycol from its cousin, ethylene glycol, which is toxic and is used primarily in antifreeze and coolant applications.. If you have specific concerns or health conditions, it is always recommended to consult a healthcare professional.
Overall, when used within approved limits and guidelines, propylene glycol is considered safe for its intended purposes.